Well there is only one more season left for Lost, so you might want to wait until they finally show....if you wanted to sit and follow the insanity that is Lost.
I go through periods of downtimes between contracts so I often have time to start catching up with shows I do that with. I honestly believe had I started watching Ugly Betty weekly, I wouldn't have grown to like it. Of course like you, I never really got Family Guy. I recorded them all, tried to watch a couple and then get to your conclusion that it's kinda funny...but yet just a bit too odd for my own liking. My friends think I'm insane, but they don't complain that I have all the episodes if they wanted to watch last weeks.